Cast
- Kiefer Sutherland as Bosco (voice)
- Judy Greer as Debbie Winslow
- Owen Wilson as Marmaduke (voice)
- William H. Macy as Don Twombly
- Christopher Mintz-Plasse as Giuseppe (voice)
- Sam Elliott as Chupadogra (voice)
- Damon Wayans Jr. as Thunder (voice)
- Marlon Wayans as Lightning (voice)
- George López as Carlos (voice)
- Emma Stone as Mazie (voice)
- Steve Coogan as Raisin (voice)
- Lee Pace as Phil Winslow
- Fergie as Jezebel (voice)
- Caroline Sunshine as Barbara Winslow
- Finley Jacobsen as Brian Winslow
