Cast
- Ron Perlman as Hotep / Ancient One #2 (voice)
- Christine Baranski as Amelia von Butch (voice)
- Virginia Madsen as Cleopatra (voice)
- Jeremy Piven as Rock Rivers (voice)
- Frank Welker as Fred Jones / Scooby-Doo (voice)
- Grey DeLisle as Daphne Blake / Natasha (voice)
- Ajay Naidu as Prince Omar (voice)
- Oded Fehr as Amahl Ali Akbar (voice)
- Casey Kasem as Shaggy Rogers (voice)
- Mindy Cohn as Velma Dinkley (voice)
- Wynton Marsalis as Campbell (voice)